The NETest is a standardized and reproducible liquid biopsy for neuroendocrine tumors (NETs). It evaluates the expression of 51 NET genes by real-time polymerase chain reaction, providing an accurate molecular profile of the neoplasm.
NET blood transcript analysis defines the crossing of the clinical Rubicon: when stable disease becomes progressive
Pavel M, Jann H, Prasad V, Drozdov I, Modlin IM, Kidd M
A key issue in Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is early identification and prediction of disease progression. Clinical evaluation and imaging are limited due to the lack of sensitivity and disease indolence. We assessed the NETest as a predictive and prognostic marker of progression in a long-term follow-up...
Circulating neuroendocrine gene transcript analysis utility in well-differentiated Paragangliomas and Pheochromocytomas
PPGLs exhibit variable malignancy, which is difficult to determine by histopathology, amine measurements or tissue genetic analyses. Circulating NET transcript analysis is positive (100% diagnostic) in well-differentiated PCC/PGL, scores were elevated in progressive disease irrespective of mutation or biochemical activity and elevated levels were prognostic.
Relationship between NETest score and clinical management; Blood NETest is an accurate diagnostic and can be of use in monitoring disease status and facilitating management change in both watch-and-wait and treatment cohorts.