Resource Library: Books & Book Chapters
The Oberndorfer Centenary: 1907-2007
At the 100th anniversary of Oberndorfer’s extraordinary contribution, Professor Modlin invited three hundred leading international physicians and scientists to celebrate the “Karzinoide” discovery. These discussions, reflecting the current status of neuroendocrine tumor disease and cutting-edge developments in the understanding of amine and peptide secretion and suppression, as well as progress in the clinical management of the ubiquitous entity of carcinoid disease, are encapsulated in this book. This text edited with Professor Oberg presents a compendium of clinical and scientific information that summarizes the advances in neuroendocrine tumor biology, pathology and clinical practice in the last century. Both we and the distinguished physicians present acknowledge and celebrate the life and times of Oberndorfer, whose great accomplishment led to the elucidation of neuroendocrine tumor disease.
Kidd M, Gustafsson BI, Modlin IM. Genetics of Gastroenteropancreatic Tumors in “Handbook of Genetics.” Brenner S (eds). 2nd edition (2013).
Gastroenteropancreatic (GEP) and bronchopulmonary (BP) neuroendocrine neoplasms (NENs) represent the second most prevalent gastrointestinal malignancy, exhibit a poor prognosis but their etiopathogenesis is unknown. This chapter explores the mechanisms and genetic basis for the etiopathogenesis of this heterogeneous disease highlighting the significantly different genetic abnormalities that occur in each tumor sub-type.
Modlin IM, Gustafsson BI, Kidd M. Neuroendocrine Tumors of the GI Tract: An appraisal of the past and perspectives for the future in “The Oxford Textbook of Endocrinology and Diabetes” Meeran K, Bloom S (eds) Oxford University Press (2nd edition) (2010).
Increased knowledge about Neuroendocrine Tumor (NET) cellular biology and their genetic characteristics is the key to the evolution of therapy. The primary goal is the need to develop a surveillance test and identify sensitive blood-based markers that facilitate early diagnosis and can define prognosis. The obvious therapeutic goal is based upon the identification of molecular targets in a particular tumor and the development of effective tumor specific targeted therapeutic agents.
Modlin IM, Kidd M, Malfertheiner MV, Gustafsson BI. Gastric Neuroendocrine Neoplasia in “The Biology of Gastrointestinal Cancers” Wang TC, Fox JG, Giraud A (eds) Springer-Verlag, NY 2008; 185-216.
Gastric “carcinoids” or, as they are currently called “NENs” (neuroendocrine neoplasms) have, in recent times, become the subject of substantial clinical and investigative interest. This reflects global concerns regarding the consequences of prolonged hypochlorhydria, long-standing hypergastrinemia (increased use of acid suppressive pharmacotherapeutic agents) as well as the proposed putative relationship between gastric adenocarcinoma and gastric NENs.